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Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented and non-conventional ways. They are also friends with their Cal Tech colleagues, mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science fiction movies or reading comic books. As they are self-professed nerds, all have little or no luck with "popular" women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment next to Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.